Journal
CLINICAL NUTRITION
Volume 40, Issue 3, Pages 912-918Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2020.06.018
Keywords
Critical illness; Enteral nutrition; Nutritional support; Amino acid tracers
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Funding
- Stockholm County Council
- Karolinska Institutet
- Swedish Physicians' Society
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The study found that there is a large intra-and inter individual variation in amino acid uptake during continuous enteral feeding. However, a tentative steady state of C-13-phenylalanine uptake is eventually reached.
Background: Amino acid availability is a regulatory factor of protein anabolism and is partly dependent on enteral amino acid uptake. During continuous enteral feeding, enteral amino acid uptake may vary considerably, but this has not been documented systematically. Methods: In this pragmatic study, we investigated patients in the intensive care unit (n = 10) and healthy adults (n = 10). The time course of essential amino acid concentrations in arterial plasma and the uptake of dietary phenylalanine were recorded during 12 hours of continuous enteral feeding, using a C-13-labeled phenylalanine tracer. Results: Plasma essential amino acid concentrations and C-13-phenylalanine enrichment reached a tentative steady state after no more than 4.5 h from start of tracer infusion. There was a large intra-and inter-individual variability in both cohorts. No periodicity could be detected in the temporal variation. Conclusion: During continuous enteral feeding, uptake of amino acids shows large intra-and inter individual variation. A tentative steady state of C-13-phenylalanine uptake is eventually reached. (C) 2020 The Author(s). Published by Elsevier Ltd.
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