4.6 Article

Evidence for normal intracortical inhibitory recruitment properties in cervical dystonia

Journal

CLINICAL NEUROPHYSIOLOGY
Volume 131, Issue 6, Pages 1272-1279

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2020.03.019

Keywords

Dystonia; Transcranial magnetic stimulation; Cortical silent period; Transcallosal inhibition; Motor evoked potential; Cortical excitability

Funding

  1. National Institutes of Health's National Center for Advancing Translational Sciences [TL1R002493, UL1TR000114, UL1TR002494]
  2. University of Minnesota Doctoral Dissertation Fellowship
  3. Foundation for Physical Therapy (Promotion of Doctoral Studies II award)
  4. Divisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, University of Minnesota
  5. University of Minnesota's MnDRIVE (Minnesota's Discovery, Research and Innovation Economy) initiative

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Objective: Dystonia is associated with reduced intracortical inhibition as measured by the cortical silent period (cSP); however, this may be due to abnormal cSP threshold or input-output properties. This study evaluated cSP recruitment properties in people with cervical dystonia (CD). Methods: Bilateral electromyographic recordings were collected in the upper trapezius muscle in response to transcranial magnetic stimulation of the left and right primary motor cortex in a group with CD (n = 19) and controls (n = 21). cSP threshold, cSP input-output properties at stimulation intensities from 1 to 1.4x the cSP threshold, ipsilateral silent period duration (iSP) and timing and magnitude of the contralateral and ipsilateral motor evoked potential (MEP) were assessed. Results: The cSP threshold, input-output properties, and contralateral MEP magnitude were not significantly different between groups (all p > 0.07). Hemispheric symmetry was present in the control group while the CD group had reduced iSP (p < 0.01) and a trend for reduced ipsilateral MEP response (p = 0.053) in the left hemisphere. Conclusions: Recruitment properties of intracortical inhibition are similar between control and CD groups. Transcallosal inhibition is asymmetric between hemispheres in people with CD. Significance: Evidence of normal intracortical inhibition recruitment properties challenge the commonly held view that cortical inhibition is reduced in dystonia. (C) 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

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