Journal
CLINICAL INFECTIOUS DISEASES
Volume 73, Issue 3, Pages E531-E539Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1143
Keywords
SARS-CoV-2; neutralizing antibodies; longitudinal dynamics; COVID-19; serological immune response
Categories
Funding
- Emergency Project from the Science and Technology Commission of Chongqing [cstc2020jscx-fyzx0053]
- Emergency Project for Novel Coronavirus Pneumonia from the Chongqing Medical University [CQMUNCP0302, CQMUNCP0304]
- Leading Talent Program of Chongqing Science and Technology Commission [CSTCCXLJRC201719]
- Science and Technology Commission of China [2017ZX10202203]
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This study found that specific neutralizing antibody titers against SARS-CoV-2 in patients with COVID-19 were initially low in the first 7-10 days after symptom onset, then gradually increased and peaked at 2-3 weeks. The titers of neutralizing antibodies and IgG levels showed a positive correlation over time, and were also significantly correlated with levels of proinflammatory cytokines.
Background. Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific neutralizing antibodies (NAbs) in patients with COVID-19. Methods. Blood samples (n = 173) were collected from 30 patients with COVID-19 over a 3-month period after symptom onset and analyzed for SARS-CoV-2-specific NAbs using the lentiviral pseudotype assay, coincident with the levels of IgG and proinflammatory cytokines. Results. SARS-CoV-2-specific NAb titers were low for the first 7-10 days after symptom onset and increased after 2-3 weeks. The median peak time for NAbs was 33 days (interquartile range [IQR], 24-59 days) after symptom onset. NAb titers in 93.3% (28/30) of the patients declined gradually over the 3-month study period, with a median decrease of 34.8% (IQR, 19.6-42.4%). NAb titers increased over time in parallel with the rise in immunoglobulin G (IgG) antibody levels, correlating well at week 3 (r = 0.41, P < .05). The NAb titers also demonstrated a significant positive correlation with levels of plasma proinflammatory cytokines, including stem cell factor (SCF), TNF-related apoptosis-inducing ligand (TRAIL), and macrophage colony-stimulating factor (M-CSF). Conclusions. These data provide useful information regarding dynamic changes in NAbs in patients with COVID-19 during the acute and convalescent phases.
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