Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid

This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate. The minimum inhibitory concentrations for BDQ and DLM were 0.25 mu g/mL and >2.0 mu g/mL, respectively.

Automated summary

This study reported a clinical case of simultaneous acquisition of resistance to bedaquiline and delamanid in Mycobacterium tuberculosis, with specific nucleotide insertions identified through whole genome sequencing. The minimum inhibitory concentrations for bedaquiline and delamanid were determined to be 0.25 μg/mL and >2.0 μg/mL, respectively.