Journal
CLINICAL INFECTIOUS DISEASES
Volume 71, Issue 10, Pages 2669-2678Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa709
Keywords
COVID-I9; H1N1; intestinal microbiota; dysbiosis; biomarker
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Funding
- National Science and Technology Major Project [2017ZX10204401]
- Zhejiang Province Key Research and Development Plan Emergency Project [2020C03123]
- National Natural Science Foundation of China [81800457, 81790631]
- Zhejiang Provincial Natural Science Foundation of China [LED20H190001]
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Background. Coronavirus disease 2019 (COVID-19) is an emerging serious global health problem. Gastrointestinal symptoms are common in COVID-19 patients, and severe acute respiratory syndrome coronavirus 2 RNA has been detected in stool specimens. However, the relationship between the gut microbiome and disease remains to be established. Methods. We conducted a cross-sectional study of 30 patients with COVID- 19, 24 patients with influenza A(H1N1), and 30 matched healthy controls (HCs) to identify differences in the gut microbiota by 16S ribosomal RNA gene V3-V4 region sequencing. Results. Compared with HCs, COVID-19 patients had significantly reduced bacterial diversity; a significantly higher relative abundance of opportunistic pathogens, such as Streptococcus, Rothia, Veillonella, and Actinomyces; and a lower relative abundance of beneficial symbionts. Five biomarkers showed high accuracy for distinguishing COVID-19 patients from HCs with an area under the curve (AUC) up to 0.89. Patients with H1N1 displayed lower diversity and different overall microbial composition compared with COVID-19 patients. Seven biomarkers were selected to distinguish the 2 cohorts (AUC = 0.94). Conclusions. The gut microbial signature of patients with COVID-19 was different from that of H1N1 patients and HCs. Our study suggests the potential value of the gut microbiota as a diagnostic biomarker and therapeutic target for COVID-19, but further validation is needed.
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