Journal
CHIMIA
Volume 74, Issue 6, Pages 450-466Publisher
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2020.450
Keywords
Bioinspired metal complexes; 2-His-1-Carboxylate facial triad; N,N,O Ligands; Non-heme iron
Categories
Funding
- European Union, under the NoNoMeCat [675020-MSCAITN-2015]
- Netherlands Organization for Scientific Research (NWO)
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Iron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations. Many of these reactions are synthetically challenging, and developing small molecular iron-based catalysts that can achieve similar reactivity and selectivity remains a long-standing goal in homogeneous catalysis. This review focuses on the development of bioinspired facial N,N,O ligands that model the 2-His-1-Carboxylate facial triad to a greater degree of structural accuracy than many of the polydentate N-donor ligands commonly used in this field. By developing robust, well-defined N,N,O facial ligands, an increased understanding could be gained of the factors governing enzymatic reactivity and selectivity.
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