Journal
CHEMOSPHERE
Volume 253, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2020.126764
Keywords
Perfluoroalkyl substances; Leydig cells; Steroidogenesis; Structure-activity relationship of PFASs
Categories
Funding
- National Natural Science Foundation of China [81730042, 81901467]
- Science and Technology Department of Zhejiang Province [2019C03035]
- Department of Health of Zhejiang Province [2018KY130]
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Perfluoroalkyl substances (PFASs) are a group of man-made organic substances. Some of PFASs have been classified as persistent organic pollutants and endocrine disruptors. They might interfere with the male sex endocrine system, causing the abnormal development of the male reproductive tract and failure of pubertal onset and infertility. The present review discusses the development and function of two generations of Leydig cells in rodents and the effects of PFASs on Leydig cell development after their exposure in gestational and postnatal periods. We also discuss human epidemiological data for the effects of PFASs on male sex hormone levels. The structure-activity relationship of PFASs on Leydig cell steroidogenesis and enzyme activities are also discussed. (C) 2020 Published by Elsevier Ltd.
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