Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 15, Issue 14, Pages 2092-2109Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202000506
Keywords
2-Pyridone; Beyond C-3; C-H Functionalizations; Transition-Metal-Catalysis; Regioselectivity
Categories
Funding
- SERB, India [CRG/2018/000630]
- SERB, India (NPDF)
- CSIR, India
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2-Pyridone is a ubiquitous motif in natural products, drug molecules, ligands in catalysis and organic materials. There is a necessity of direct step-economic methods for the construction of 2-pyridone based molecules. Strategically, the primary developments have led to the C3-functionalizations due to the inherent reactivity of this center. Despite this, many elegant transition metal-catalysed methods have been established to introduce versatile functional groups at the C4, C5 and C6-position via direct C-H bond functionalizations. This minireview focuses on the categorized introduction of different functional groups at the 2-pyridone scaffolds beyond C3-selectivity and discusses substrate scope, limitations and plausible mechanistic details.
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