Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 44, Pages 9846-9850Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202002442
Keywords
biofilm; MRSA; natural products; structure elucidation; total synthesis
Categories
Funding
- Fonds der Chemischen Industrie (FCI)
- Universitat Hamburg
- Rahn-Quade foundation
Ask authors/readers for more resources
Diorcinols and related prenylated diaryl ethers were reported to exhibit activity against methicillin-resistant clinical isolates ofStaphylococcus aureus(MRSA). Within these lines, we report the first total synthesis of diorcinol D, I, J, the proposed structure of verticilatin and recently isolated antibacterial diaryl ether by using an efficient and highly divergent synthetic strategy. These total syntheses furnish the diaryl ethers in only five to seven steps employing a Pd-catalyzed diaryl ether coupling as the key step. The total synthesis led to the structural revision of the natural product verticilatin, which has been isolated from a plant pathogenic fungus. Furthermore, these structures were tested in order to determine their antibacterial activities against different MRSA strains as well as further Gram-positive and -negative bacteria.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available