Chiral Catalysts for Pd0-Catalyzed Enantioselective C-H Activation

In the past few decades, processes that involve transition-metal catalysis have represented a major part of the synthetic chemist ' s toolbox. Recently, the interest has shifted from the well-established cross-coupling reactions to C-H bond functionalization, thus making it a current frontier of transition-metal-catalyzed reactions. Constant progress in this field has led to the discovery of enantioselective methods to generate and control various types of stereogenic elements, thereby demonstrating its high value to generate scalemic chiral molecules. The present review is dedicated to enantioselective Pd-0-catalyzed C-H activation, which may be considered as an evolution of Pd-0-catalyzed cross-couplings, with a focus on the different chiral ligands and catalysts that enable these transformations.

Automated summary

Processes involving transition-metal catalysis have become a major part of synthetic chemists' toolbox in recent decades. The focus has shifted from cross-coupling reactions to C-H bond functionalization, with constant progress leading to discovery of enantioselective methods. The review discusses enantioselective Pd-0-catalyzed C-H activation, highlighting the importance of different chiral ligands and catalysts in enabling these transformations.