Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 27, Issue 2, Pages 565-576Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202002866
Keywords
cycloaddition; fused ring systems; natural products; small ring systems; strained molecules
Categories
Funding
- Indiana University
- National Institutes of Health [R35GM131755]
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The ladderane family of natural products is famous for their linearly concatenated cyclobutane skeletal structure, and since their discovery in 2002, several chemical syntheses have been reported. This review focuses on showcasing the novel tactics used to generate the ladderane core and the challenges associated with synthesizing these unusual and complex natural products.
The ladderane family of natural products are well known for their linearly concatenated cyclobutane skeletal structure. Owing to their unique carbocyclic framework, several chemical syntheses have been reported since their discovery in 2002. The focus of this review is to showcase the novel tactics that have been used to generate the ladderane core and the challenges that are associated with the synthesis of these unusual and complex natural products.
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