Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 56, Issue 4, Pages 651-655Publisher
SPRINGER
DOI: 10.1007/s10600-020-03114-y
Keywords
Eupatorium chinenseL; Michael addition acceptor; sesquiterpene lactone; anti-TNBC activity
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Funding
- National Natural Science Foundation of China [81773868]
- Natural Science Foundation of Zhejiang Province [LY17H280004]
- Zhejiang Province Chinese medicine scientific research fund project [2016ZA050]
- Hangzhou Major Science and Technology Project [20172016A01]
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A new sesquiterpene lactone, namely, eupachiilide A (1), as well as two known sesquiterpene lactones, eupachinilide B (2), and eupalinilide G (3), were isolated from the whole plant of Eupatorium chinense L. The new structure was elucidated by spectral methods, especially 2D NMR techniques. The three natural compounds were all Michael addition acceptors, whose electrophilic moiety could react with the nucleophilic residues of the relevant active site and produce a variety of bioactivities. Eupachiilide A demonstrated potent cytotoxicity against two TNBC cell lines.
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