Journal
CHEMISTRY OF MATERIALS
Volume 32, Issue 13, Pages 5759-5767Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.0c01573
Keywords
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Funding
- MURI grant through the Air Force Office of Scientific Research [FA9550-18-1-0142]
- National Science Foundation [CHE-1900422]
- Northwestern University
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Melanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma rays. In this work, we aimed to increase the radical content by introducing nitroxide radicals into synthetic melanin nanomaterials. Nanoparticles (NPs) were prepared by co-polymerization of a stable radical modified monomer with the monomer dopamine. The radical content increased to 1 order of magnitude higher than that of the conventional melanin-like material, polydopamine. These radical NPs can enter human epidermal keratinocytes and form perinuclear caps, mimicking natural melanin synthesized by melanocytes. We demonstrated that these NPs display protective properties by scavenging reactive oxygen species, one of the most important biological effects of ionizing radiation exposure. This finding may have potential application for materials capable of mitigating side effects of clinical radiation therapy.
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