Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 56, Issue 6, Pages 722-726Publisher
SPRINGER
DOI: 10.1007/s10593-020-02722-4
Keywords
peroxides; tetraoxanes; anticancer activity; heterogeneous catalysis; ion exchange resin; peroxidation
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Funding
- Russian Foundation for Basic Research [18-53-15010]
- Projects de Recherche Conjoints (PRC) - CNRS, PRC Russie 2017 CNRS
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Bridged 1,2,4,5-tetraoxanes were prepared using available acidic ion exchange resin with high yields despite the possibility of peroxide decomposition under heterogeneous conditions. The bridged tetraoxanes demonstrated high cytotoxicity against HeLa cancer cellsin vitro, which in some cases was higher than that of cisplatin, artesunate, and dihydroartemisinin.
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