Journal
CHEMICAL REVIEWS
Volume 120, Issue 15, Pages 7348-7398Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.9b00384
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21672097, 21972064, 21901111]
- National Natural Science Foundation of Jiangsu Province [BK20170632]
- Innovation & Entrepreneurship Talents Plan of Jiangsu Province
- Outstanding Youth Funds of Jiangsu Province
Ask authors/readers for more resources
Organoborons have emerged as versatile building blocks in organic synthesis to achieve molecular diversity and as carboxylic acid bioisosteres with broad applicability in drug discovery. Traditionally, these compounds are prepared by the substitution of Grignard/lithium reagents with electrophilic boron species and Brown hydroboration. Recent developments have provided new routes for the efficient preparation of organoborons by applying reactions using chemical feedstocks with leaving groups. As compared to the previous methods that used organic halides (I, Br, and Cl), the direct borylation of less reactive C-Het and C-C bonds has become highly important to get efficiency and functional-group compatibility. This Review aims to provide a comprehensive overview of this topic, including (1) C-F bond borylation, (2) C-O bond borylation, (3) C-S bond borylation, (4) C-N bond borylation, and (5) C-C bond borylation. Considerable attention is given to the strategies and mechanisms involved. We expect that this Review will inspire chemists to discover more efficient transformations to expand this field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available