4.6 Article

Power-saving airlift bioreactor with helical sieve plates: Developmental and performance studies

Journal

CHEMICAL ENGINEERING RESEARCH & DESIGN
Volume 158, Issue -, Pages 1-11

Publisher

ELSEVIER
DOI: 10.1016/j.cherd.2020.03.014

Keywords

Airlift reactor; Draft tube; Volumetric oxygen transfer coefficient; Gas holdup; Mixing time; Pichia pastoris

Funding

  1. National Natural Science Foundation of China [31271888]
  2. Fundamental Research Funds for the Central Universities [JUSRP51632A]
  3. National Key Research and Development Program of China [2017YFD0400302]

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This study investigated the influence of the geometry of the draft tube on the mass transfer and energy efficiency in the airlift reactor with helical sieve plate (ALR-HSP). The power consumption efficiency was 46%-53% higher than the control condition by optimizing the draft tube. A set of empirical equations was used to describe the gas holdup and volumetric mass transfer coefficients corresponding to the geometry of draft tubes in the ALR-HSP for the water-air system. The comparative cultivation of Pichia pastoris was carried out using the ALR-HSP and the conventional airlift reactor (CALR). The biomass increased by 20%, the maximal specific growth rate during the logarithmic growth phase nearly doubled, and volumetric oxygen transfer coefficient increased by 21%-47% under the same culture conditions. Results preliminarily demonstrated the superior performance and practicability of the ALR-HSP in enhancing oxygen transfer efficiency and aerobic biological reaction efficiency. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

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