Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 68, Issue 7, Pages 671-674Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c20-00080
Keywords
Artocarpus lakoocha; cytotoxic activity; antimycobacterial activity; antiplasmodial activity
Funding
- Science Achievement Scholarship of Thailand
- Graduate School, Chiang Mai University
- Office of the Higher Education Commissions [MRG5980004]
- Thailand Research Fund [MRG5980004]
- Chiang Mai University
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Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 w ith IC50 values of 36.7 and 33.9 mu M, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 mu M. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 mu M.
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