Development of Transition-Metal-Catalysed Cross-Coupling Reactions through Ammonium C-N Bond Cleavage

In this review, we summarize our recent progress on functionalization of the ammonium C-N bond through a transition-metal-catalysed cross-coupling process. By synergistic utilization of computational and experimental methods, we have successfully developed several new C-N bond cleavage protocols and established new reaction mechanisms. These findings provide new possibilities for transforming naturally abundant chemicals into useful functional molecules in an efficient and selective manner.