Journal
CHROMOSOMA
Volume 125, Issue 4, Pages 645-659Publisher
SPRINGER
DOI: 10.1007/s00412-016-0608-3
Keywords
Kinetochore; Centromere; CCAN; KMN; Cell cycle
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
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The kinetochore is an essential structure for the chromosome segregation machinery in eukaryotes; it serves as a bridge between the spindle microtubules and chromosomes. The kinetochore consists of multiple interconnecting components on the centromere; therefore, understanding its formation, molecular function, and regulation has remained an ongoing challenge. Recent studies have provided new insights into centromere identity, kinetochore assembly, and function. In this review, we discuss recent advances in our understanding of the function and regulation of key kinetochore components. We highlight the reciprocal localization dependencies of the different sub-complexes of the kinetochore and describe their regulation during the cell cycle.
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