Journal
CHEMBIOCHEM
Volume 22, Issue 3, Pages 460-468Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202000437
Keywords
noncanonical amino acids; post-translational modifications; synthetic biosafety
Funding
- National Research Foundation of Korea [2017R1A2B3011543]
- Samsung Science & Technology Foundation [SSTF-BA1702-09]
- National Research Foundation of Korea [2017R1A2B3011543] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The synthesis of noncanonical amino acids (ncAAs) has been extensively studied for its broad applicability in generating synthetic recombinant proteins, particularly in the fields of synthetic biosafety and post-translational modification research.
The incorporation of noncanonical amino acids (ncAAs) has been extensively studied because of its broad applicability. In the past decades, various in vitro and in vivo ncAA incorporation approaches have been developed to generate synthetic recombinant proteins. Herein, we discuss the methodologies for ncAA incorporation, and their use in diverse research areas, such as in synthetic biosafety and for studies of post-translational modifications.
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