Journal
CHEMBIOCHEM
Volume 21, Issue 23, Pages 3313-3318Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202000295
Keywords
branched ubiquitin chains; chemical ubiquitylation; protein chemical synthesis; ubiquitin probes
Funding
- National Key R&D Program of China [2017YFA0505200]
- National Natural Science Foundation of China [91753205, 21877024]
- Fundamental Research Funds for the Central Universities [JZ2019HGPB0105]
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Ubiquitin chains with distinct topologies play essential roles in eukaryotic cells. Recently, it was discovered that multiple ubiquitin units can be ligated to more than one lysine residue in the same ubiquitin to form diverse branched ubiquitin chains. Although there is increasing evidence implicating these branched chains in a plethora of biological functions, few mechanistic details have been elucidated. This concept article introduces the function, detection and chemical synthesis of branched ubiquitin chains; and offers some future perspective for this exciting new field.
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