Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 78, Issue 2, Pages 497-512Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03579-8
Keywords
Hippo; Mechanisms; Regulation; Signaling pathways; TAZ; YAP
Categories
Funding
- National Key R&D Program of China [2018YFC1105303/04]
- National Natural Science Foundation of China [51772006, 31670993, 51973004, 81991505]
- Beijing Municipal Science & Technology Commission Projects [Z181100002018001]
- Peking University Medicine Fund [PKU2020LCXQ009, BMU2020PYB029]
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YAP and TAZ are crucial proteins involved in maintaining tissue/organ size and have diverse roles in various biological processes, including cell proliferation, tissue regeneration, cell fate determination, tumorigenesis, and mechanosensing.
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.
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