Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 78, Issue 1, Pages 63-78Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-020-03587-8
Keywords
RIPK3; NLRP3 inflammasome; ROS; mPTP opening; Myocarditis; Cardiotoxicity
Categories
Funding
- National Natural Science Foundation of China [81872873, 81573430]
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Apoptosis, necrosis, and autophagy-dependent cell death are the three major types of cell death. Regulated necrosis, with various forms such as necroptosis, pyroptosis, and ferroptosis, plays a significant role in the progression of injury-relevant diseases. Further research focusing on the crosstalk among different types of regulated necrosis is needed for developing efficient strategies for reducing cardio-cerebrovascular injury.
Apoptosis, necrosis and autophagy-dependent cell death are the three major types of cell death. Traditionally, necrosis is thought as a passive and unregulated form of cell death. However, certain necrosis can also occur in a highly regulated manner, referring to regulated necrosis. Depending on the signaling pathways, regulated necrosis can be further classified as necroptosis, pyroptosis, ferroptosis, parthanatos and CypD-mediated necrosis. Numerous studies have reported that regulated necrosis contributes to the progression of multiple injury-relevant diseases. For example, necroptosis contributes to the development of myocardial infarction, atherosclerosis, heart failure and stroke; pyroptosis is involved in the progression of myocardial or cerebral infarction, atherosclerosis and diabetic cardiomyopathy; while ferroptosis, parthanatos and CypD-mediated necrosis participate in the pathological process of myocardial and/or cerebral ischemia/reperfusion injury. Thereby, targeting the pathways of regulated necrosis pharmacologically or genetically could be an efficient strategy for reducing cardio-cerebrovascular injury. Further study needs to focus on the crosstalk and interplay among different types of regulated necrosis. Pharmacological intervention of two or more types of regulated necrosis simultaneously may have advantages in clinic to treat injury-relevant diseases.
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