Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 17, Issue 7, Pages 712-721Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/s41423-020-0480-1
Keywords
Mitochondrial dynamics; Metabolism; T cell; B cell; Innate immune cell
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Funding
- Excellent Young Scientist Foundation of NSFC [31822017]
- Zhejiang Provincial Natural Science Foundation of China [LR19C080001]
- National Natural Science Foundation of China [81572651, 81771675]
- Fundamental Research Funds for the Central Universities
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Mitochondria are highly mobile organelles due to fission, fusion, transport, and mitophagy, and these processes are known as mitochondrial dynamics. Mitochondrial dynamics play an important role in energy production, cell division, cell differentiation, and cell death. In the past decade, numerous studies have revealed the importance of mitochondrial metabolism in immunity, and mitochondrial dynamics are essential for immune responses mediated by various cell types. In this review, we mainly discuss the role of mitochondrial dynamics in activation, differentiation, cytokine production, and the activity of related pathways in immune cells, particularly T cells, B cells, and other cells involved in the innate immune response.
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