Journal
CELLS TISSUES ORGANS
Volume 211, Issue 2, Pages 91-109Publisher
KARGER
DOI: 10.1159/000510103
Keywords
Non-small-cell lung cancer; Epithelial-mesenchymal transition; Therapy; Resistance
Funding
- Partenariat Hubert Curien-Tournesol
- Senior Associate Researcher from FRS-FNRS (Belgium)
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The paper reviews the clinical and histological features of non-small-cell lung cancer associated with EMT and explores the potential clinical implications of EMT in lung cancer treatment.
Lung cancer is one of the most common solid cancers and represents the leading cause of cancer death worldwide. Over the last decade, research on the epithelial-mesenchymal transition (EMT) in lung cancer has gained increasing attention. Here, we review clinical and histological features of non-small-cell lung cancer associated with EMT. We then aimed to establish potential clinical implications of EMT in current therapeutic options, including surgery, radiation, targeted therapy against oncogenic drivers, and immunotherapy.
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