Journal
CELL RESEARCH
Volume 30, Issue 7, Pages 558-559Publisher
SPRINGERNATURE
DOI: 10.1038/s41422-020-0351-4
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Secretory IgA (SIgA) is a specialized form of antibody present at high concentrations in mucosal secretions, where it acts as the first line of defense of the immune system. In a recent paper published in Cell Research, Wang et al. present cryo-EM structures revealing the architecture of SIgA and its interactions with SpsA, a pneumococcal adhesin that piggybacks on SIgA to facilitate gut colonization and host cell invasion by Streptococcus pneumoniae.
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