Journal
CELL RESEARCH
Volume 30, Issue 9, Pages 713-714Publisher
SPRINGERNATURE
DOI: 10.1038/s41422-020-0382-x
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Cytosolic proteins lacking a signal peptide are often loaded into vesicles and secreted via unconventional protein secretion pathways. A recent paper in Cell identifies the transmembrane protein TMED10 as a protein channel for the vesicular translocation and secretion of mature IL-1 beta and other leaderless cargoes.
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