Journal
CELL HOST & MICROBE
Volume 28, Issue 2, Pages 285-+Publisher
CELL PRESS
DOI: 10.1016/j.chom.2020.06.009
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Funding
- Heart and Stroke Foundation
- Canadian Lung Association Emerging Research Leaders Initiative
- Canadian Respiratory Research Network
- AllerGen NCE
- University of Manitoba
- Canadian Foundation for Innovation
- Research Manitoba
- Genome Canada [274CHI, FDN-159935, EC1-144621]
- Canada Research Chairs Program
- Research Manitoba Doctoral Studentship
- CIHR Vanier Canada Graduate Scholarship
- University of British Columbia
- Vancouver Coastal Health-CIHR-UBC MD/PhD Studentship Award
- CIHR
- Natural Sciences and Engineering Research Council of Canada (NSERC)
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Gut microbiota play a critical role in infant health. It is now accepted that breastmilk contains live bacteria from endogenous and exogenous sources, but it remains unclear whether these bacteria transfer to the infant gut and whether this process is influenced by breastmilk feeding practices. Here, we show that certain bacteria, including Streptococcus spp. and Veillonella dispar, co-occur in mothers' milk and their infants' stool, and co-occurrence is reduced when infants receive pumped breastmilk. The relative abundances of commonly shared species are positively correlated between breastmilk and stool. Overall, gut microbiota composition is strongly associated with breastfeeding exclusivity and duration but not breastmilk feeding mode (nursing versus pumping). Moreover, breastmilk bacteria contributed to overall gut microbiota variation to a similar extent as other modifiers of the infant microbiome, such as birth mode. These results provide evidence that breastmilk may transfer bacteria to the infant gut and influence microbiota development.
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