Journal
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
Volume 97, Issue 2, Pages E198-E208Publisher
WILEY
DOI: 10.1002/ccd.28962
Keywords
DES-drug-eluting stent; LM-left main distal bifurcation lesion; PCI-percutaneous coronary intervention; DSS-double stent technique
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Clinical outcomes were significantly improved with current generation drug eluting stents (cDES) compared to early generation drug eluting stents (eDES) in patients with unprotected distal left main disease (ULMD) treated with double stent strategy (DSS), mainly due to reduction in target lesion revascularization (TLR) at the ostium of left circumflex artery (LCX).
Background There are only little data available on the comparison of clinical outcomes between a early generation drug eluting stent (eDES) and a current generation drug eluting stent (cDES) for percutaneous coronary intervention (PCI) with double stent strategy (DSS) for unprotected distal left main disease (ULMD). Methods Between April 2005 and December 2015, we recruited 452 consecutive ULMD patients treated with DSS (eDES, 236 patients; cDES, 216 patients). In this study, eDES included Cipher, Taxus, and Endeavor and cDES included Ultimaster, Resolute family, Xience family, Promus family, Synergy, and Nobori. The primary endpoint was target lesion failure (TLF) defined as a composite of cardiac death, target lesion revascularization (TLR) and myocardial infarction (MI) during the median follow-up period of 1,809(IQR: 1,190-2,510) days. Results In entire population, the rate of overall TLR was significantly lower in cDES group than that in eDES group (adjusted HR 0.62, 95% CI 0.40-0.96, p = .032). The rate of TLR for the ostium of LCX was significantly lower in cDES group than that in eDES group (adjusted HR 0.63, 95% CI 0.39-0.99, p = .047). Cardiac mortality, the rate of TLR for LM-LAD, MI and definite/probable ST did not significantly differ between both groups. The results were preserved in the propensity adjusted population. Conclusions cDES significantly improved the clinical outcomes in population treated with DSS mainly driven by the reduction of TLR for the ostium of LCX.
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