Journal
CATALYSIS TODAY
Volume 388, Issue -, Pages 231-236Publisher
ELSEVIER
DOI: 10.1016/j.cattod.2020.07.014
Keywords
Hierarchical bimodal porous silica gel; Palladium column; Suzuki-Miyaura cross coupling; Flow chemistry
Funding
- JSPS KAKENHI [JP15H05849, 2707, JP26288049, JP26220804, JP25220913, JP17865428]
- AMED [JP19ak0101090]
- Japan Science and Technology Agency's (JST) A-step program, CREST [18067420]
- Ogasawara Foundation for the Promotion of Science Engineering
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A novel strategy involving hierarchical bimodal porous silica gel supported palladium column reactors has been demonstrated to increase the unit-time-productivity of flow synthesis. The reactors, with low pressure drop due to the significantly large surface area of HBPSG, enable high-volume production. Flow synthesis of the precursor of adapalene, a pharmaceutical compound, was achieved at a rate of 5 g/h, over 10-fold greater productivity than previous approaches.
We describe a novel strategy to increase the unit-time-productivity of flow synthesis by using hierarchical bimodal porous silica gel (HBPSG) supported palladium column reactors. Because HBPSG has a significantly large surface area, the column reactors have low pressure drop, enabling high-volume production. We demonstrated flow synthesis of the precursor of adapalene, a pharmaceutical compound, at 5 g/h which is over 10-fold greater productivity than previous approaches.
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