Journal
CARBOHYDRATE POLYMERS
Volume 241, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116364
Keywords
Hyaluronic acid; Wound dressing; Wound healing
Categories
Funding
- FEDER funds through the POCI - COMPETE 2020 - Operational Programme Competitiveness and Internationalization in Axis I-Strengthening research, technological development [POCI-01-0145-FEDER-007491]
- National Funds by FCT - Foundation for Science and Technology [UID/Multi/00709/2013]
- UBI-Santander/Totta
- [CENTRO-01-0145-FEDER-028989]
- [POCI-01-0145-FEDER-031462]
- Fundação para a Ciência e a Tecnologia [UID/Multi/00709/2013] Funding Source: FCT
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Hyaluronic acid (HA), a non-sulfated glycosaminoglycan (GAG), is a major component of skin extracellular matrix (ECM) and it is involved in the inflammatory response, angiogenesis, and tissue regeneration process. Due to the intrinsic properties of HA (such as biocompatibility, biodegradability and hydrophilic character), it has been used to produce different wound dressings, namely sponges, films, hydrogels, and electrospun membranes. Herein, an overview of the different HA-based wound dressings that have been produced so far is provided as well as the future directions regarding the strategies aimed to improve the mechanical stability of HA-based wound dressings, along with the incorporation of biomolecules intended to ameliorate their biological performance during the healing process.
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