Journal
CANCER SCIENCE
Volume 111, Issue 10, Pages 3468-3477Publisher
WILEY
DOI: 10.1111/cas.14578
Keywords
cancer stemness; cancer-associated fibroblast; chemoresistance; immunotherapy; metabolic modulation
Categories
Funding
- Japan Society for the Promotion of Science [20H03531]
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [20H03531] Funding Source: KAKEN
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The effectiveness of current chemotherapies for cancer is gradually progressing; however achieving a complete cure through chemotherapy is still difficult and has been the main goal in treatment of advanced cancer. Drug resistance is an issue in cancer therapy, therefore increasing numbers of investigations into drug resistance have focused on the characteristics of the cancer cells themselves. The interaction between the tumor microenvironment (TME) and cancer cells is also intimately involved in the development of drug resistance. Cancer-associated fibroblasts (CAFs) are a predominant component of the TME and affect tumor progression by secreting soluble factors. This review summarizes the most up-to-date knowledge of CAFs and drug resistance in cancer, with a focus on factors secreted from CAFs including proteins, cytokines, extracellular vesicles, and metabolites. A perspective on the potential role of anti-CAF therapies in overcoming CAF-induced drug resistance is also discussed.
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