Journal
CANCER SCIENCE
Volume 111, Issue 9, Pages 3100-3110Publisher
WILEY
DOI: 10.1111/cas.14563
Keywords
cancer; exosomes; immunomodulation; mesenchymal stem cells; MSC-derived exosomes
Categories
Funding
- NCI [5R01CA231465]
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Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition and biological functions as well as the therapeutic potential of MSC-derived exosomes in cancer, with a focus on clinical translation opportunities.
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