Journal
CANCER RESEARCH
Volume 80, Issue 20, Pages 4307-4313Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-20-0032
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Funding
- National Natural Science Foundation of China [81972663, 81560385]
- Key Scientific Research Projects of Institutions of Higher Education in Henan Province [19A310024]
- China Postdoctoral Science Foundation [2019T120648, 2017M610462]
- National Natural Science Foundation of Henan Province [182300410342]
- Health Commission Technology Talents Overseas Training Project of Henan Province [2018140]
- Key Scientific Research Project of Henan Higher Education Institutions [20A310024]
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Tumor drug resistance is a major challenge in the treatment of cancer. Noncoding RNAs (ncRNA) play a role in the progression of drug resistance. Recent studies have indicated that exosomes, with their in vitro and in vivo compatibility, are the best natural carrier of ncRNA, and their transport of ncRNA into cells could regulate drug resistance. Exosomal ncRNA impact drug resistance through participation in drug efflux, regulation of signaling pathways, and modification of the tumor microenvironment. In this review, we evaluate the mechanism of exosomal ncRNA related to tumor drug resistance, their role in different tumors, and potential clinical applications.
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