Journal
CANCER LETTERS
Volume 483, Issue -, Pages 35-45Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.04.014
Keywords
Hypoxia; Epithelial-mesenchymal transition; lncRNA; Metastasis
Categories
Funding
- Ministry of Science and Technology [MOST 107-2745-B-039-001, MOST 108-2321-B-182A-005, MOST 108-2628-B-039-003]
- Chang Gung Memorial Hospital [OMRPG3I0011, NMRPG3H0651, CORPG3J0231, NMRPG3J0671]
- China Medical University [CMU-108-MF105]
- Drug Development Center, China Medical University from The Featured Areas Research Center Program (Ministry of Education, Taiwan)
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Hypoxia-induced long noncoding RNAs (lncRNAs) have been shown to induce tumor metastasis. However, lncRNAs that are regulated by hypoxia/HIF-1 alpha and subsequently control the expression of multiple epithelial-mesenchymal transition (EMT) regulators have not been identified. To identify such lncRNAs, analysis of RNA-sequencing datasets was performed. The lncRNA RP11-390F4.3 was shown to be induced by hypoxia and directly activated by HIF-1 alpha. Overexpression of lncRNA RP11-390F4.3 induced EMT and metastasis. LncRNA RP11-390F4.3 was essential for hypoxia-induced EMT and metastasis. LncRNA RP11-390F4.3 overexpression induced the expression of multiple EMT regulators. This report demonstrates that LncRNA RP11-390F4.3 is induced by hypoxia/HIF-1 alpha and is essential for hypoxia-induced EMT and metastasis via the activation of multiple EMT regulators.
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