Journal
CANCER LETTERS
Volume 492, Issue -, Pages 11-20Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2020.07.028
Keywords
Neutrophils; Circulating tumor cells; Metastasis; Tumor cell dissemination; Tumor microenvironment
Categories
Funding
- National Natural Science Foundation of China [81702907, 81772901, 81772928, 81803025, 81872278, 81972776]
- Natural Science Foundation of Hunan Province [2018JJ2247, 2018JJ3704, 2018JJ3815, 2018SK21210, 2018SK21211, 2019JJ50354, 2019JJ50872, 2020JJ4766]
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Metastasis is a critical cause of treatment failure and death in patients with advanced malignancies. Tumor cells can leave the primary site and enter the bloodstream; these circulating tumor cells then colonize target organs by overcoming blood shear stress, evading immune surveillance, and silencing the offensive capabilities of immune cells, eventually forming metastatic foci. From leaving the primary focus to the completion of distant metastasis, malignant tumor cells are supported and/or antagonized by certain immune cells. In particular, it has been found that myeloid granulocytes play an important role in this process. This review therefore aims to comprehensively describe the significance of neutrophils in solid tumor metastasis in terms of their supporting role in initiating the invasion and migration of tumor cells and assisting the colonization of circulating tumor cells in distant target organs, with the hope of providing insight into and ideas for anti-tumor metastasis treatment of tumor patients.
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