Journal
CANCER CELL
Volume 37, Issue 6, Pages 786-+Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2020.05.002
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Funding
- Cancer Research Institute (United States)
- NIH (United States) [5T32AI007334-28]
- Human Frontier Science Program Fellowship [LT000061/2018-L, U54CA163123, 5U01CA217864, R21CA191428, R01CA197363]
- DRC Center grant NIH [P30 DK063720]
- NIH S10 Instrumentation grant [S10 1S10OD018040-01]
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Generation of tumor-infiltrating lymphocytes begins when tumor antigens reach the lymph node (LN) to stimulate T cells, yet we know little of how tumor material is disseminated among the large variety of antigen-presenting dendritic cell (DC) subsets in the LN. Here, we demonstrate that tumor proteins are carried to the LN within discrete vesicles inside DCs and are then transferred among DC subsets. A synapse is formed between interacting DCs and vesicle transfer takes place in the absence of free exosomes. DCs -containing vesicles can uniquely activate T cells, whereas DCs lacking them do not. Understanding this restricted sharing of tumor identity provides substantial room for engineering better anti-tumor immunity.
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