Journal
CHIRALITY
Volume 28, Issue 3, Pages 169-180Publisher
WILEY
DOI: 10.1002/chir.22566
Keywords
norcoclaurine; enantioselective HPLC; norcoclaurine synthase; enantioselective synthesis; chemoenzymatic synthesis
Funding
- Center for Life NanoScience@Sapienza, Istituto Italiano di Tecnologia (IIT), Roma, Italy
- Sapienza Universita di Roma, Italy
Ask authors/readers for more resources
This review article is aimed at providing a monographic overview on (S)-norcoclaurine (NC) alkaloid from three diverse points of view, collected all together for the first time: 1) the synthetic one, where the compound is seen as a target chiral molecule to be obtained in the highest optical purity and as a starting point for the development of biocatalytic asymmetric syntheses of tetrahydroisoquinoline alkaloids; 2) the chromatographic one, which addresses the HPLC separation of the two NC enantiomers; and 3) the biochemical one, for which a thorough understanding of the topology and mechanism of action of norcoclaurine synthase (NCS) enzyme is still a matter of debate. Special emphasis on the most recent studies in the field is given by discussing the results published by the main research groups who are working on NC and NCS. Chirality 28:169-180, 2016. (c) 2016 Wiley Periodicals, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available