Journal
CANCER AND METASTASIS REVIEWS
Volume 39, Issue 4, Pages 1223-1243Publisher
SPRINGER
DOI: 10.1007/s10555-020-09924-4
Keywords
Peritoneal metastasis; Pancreatic adenocarcinoma; Gastric cancer; Ovarian cancer
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Funding
- Intramural Research Program of the NIH, Center for Cancer Research, National Cancer Institute
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Pancreatic cancer is the third leading cause of cancer death in the USA, and pancreatic ductal adenocarcinoma (PDA) constitutes 85% of pancreatic cancer diagnoses. PDA frequently metastasizes to the peritoneum, but effective treatment of peritoneal metastasis remains a clinical challenge. Despite this unmet need, understanding of the biological mechanisms that contribute to development and progression of PDA peritoneal metastasis is sparse. By contrast, a vast number of studies have investigated mechanisms of peritoneal metastasis in ovarian and gastric cancers. Here, we contrast similarities and differences between peritoneal metastasis in PDA as compared with those in gastric and ovarian cancer by outlining molecular mediators involved in each step of the peritoneal metastasis cascade. This review aims to provide mechanistic insights that could be translated into effective targeted therapies for patients with peritoneal metastasis from PDA.
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