Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 193, Issue 3, Pages 551-555Publisher
WILEY
DOI: 10.1111/bjh.16793
Keywords
myeloma; transplantation; prognostic factors
Categories
Funding
- Cancer Research UK [C1298/A10410]
- Celgene Corporation
- Merck Sharp and Dohme
- Myeloma UK
- Jacquelin Forbes-Nixon Fellowship
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Despite equal access to subsequent therapies, myeloma patients who relapse early within 12 months of autologous stem cell transplant have significantly worse progression-free survival and overall survival compared to later relapsing patients, highlighting the urgent need for improved outcome prediction and early intervention strategies.
Predicting patient outcome in multiple myeloma remains challenging despite the availability of standard prognostic biomarkers. We investigated outcome for patients relapsing early from intensive therapy on NCRI Myeloma XI. Relapse within 12 months of autologous stem cell transplant was associated with markedly worse median progression-free survival 2 (PFS2) of 18 months and overall survival (OS) of 26 months, compared to median PFS2 of 85 months and OS of 91 months for later relapsing patients despite equal access to and use of subsequent therapies, highlighting the urgent need for improved outcome prediction and early intervention strategies for myeloma patients.
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