Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 190, Issue 4, Pages 520-524Publisher
WILEY
DOI: 10.1111/bjh.16938
Keywords
contact system; serpins; virology; complement; SARS-CoV-2
Categories
Funding
- Spanish Science Council (CSIC) - Spanish Ministry of Science and Innovation [COVID-006]
- [RTI 2018-096055-B-100]
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Coronavirus disease 2019 (COVID-19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life-threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus-2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen-specific mechanism that may help explain significant systemic abnormalities in patients with COVID-19.
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