Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 191, Issue 2, Pages 207-211Publisher
WILEY
DOI: 10.1111/bjh.17034
Keywords
COVID-19; CD95 (Fas); PD-1; apoptosis; exhaustion
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A low count of CD4(+)and CD8(+)lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4(+)T and CD8(+)T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4(+)cells correlated with lower CD4(+)counts. A higher expression of CD95 in CD4(+)and CD8(+)lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection.
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