Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 193, Issue 1, Pages 119-124Publisher
WILEY
DOI: 10.1111/bjh.16806
Keywords
multiple myeloma; prognosis; Myeloma Risk Profile; geriatric; survival
Categories
Funding
- Danish Cancer Society
- Academy of Geriatric Cancer Research (AgeCare), Odense University Hospital, Denmark
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The study validated the predictive value of MRP in transplant ineligible MM patients above 65 years, stratifying patients into different risk groups and showing a higher risk of early death in high-risk patients compared to low-risk patients.
In 2019 the UK Myeloma Research Alliance introduced the Myeloma Risk Profile (MRP) for prediction of outcome in patients with newly diagnosed multiple myeloma (MM), ineligible for autologous stem cell transplantation. To validate the MRP in a population-based setting we performed a study of the entire cohort of transplant ineligible MM patients above 65 years in the Danish National MM Registry. Our data confirmed the value of the MRP. In a cohort of 1,377 patients, the MRP score separated patients into three distinct risk-groups with an observed hazard ratio of 2.91 for early death in high-risk versus low-risk patients.
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