Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 190, Issue 5, Pages 718-722Publisher
WILEY
DOI: 10.1111/bjh.16943
Keywords
COVID-19; SARS-Cov-2; coronavirus; plasmacytoid lymphocytes; white blood cells scattergram
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Complementary tools are warranted to increase the sensitivity of the initial testing for COVID-19. We identified a specific 'sandglass' aspect on the white blood cell scattergram of COVID-19 patients reflecting the presence of circulating plasmacytoid lymphocytes. Patients were dichotomized as COVID-19-positive or -negative based on reverse transcriptase polymerase chain reaction (RT-PCR) and chest computed tomography (CT) scan results. Sensitivity and specificity of the 'sandglass' aspect were 85 center dot 9% and 83 center dot 5% respectively. The positive predictive value was 94 center dot 3%. Our findings provide a non-invasive and simple tool to quickly categorize symptomatic patients as either COVID-19-probable or -improbable especially when RT-PCR and/or chest CT are not rapidly available.
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