Journal
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Volume 87, Issue 3, Pages 1033-1042Publisher
WILEY
DOI: 10.1111/bcp.14461
Keywords
antibiotics; antimicrobial resistance; antimicrobial stewardship; drug utilization; prescriptions
Categories
Funding
- Working Group of the National Observatory for Medicines Use Monitoring
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In Italy, both antibiotic consumption and bacterial resistance rates are higher than in other European countries. The study found that in 2018, the consumption of antibiotics in Italy was 16.1 DDD per 1000 inhabitants per day, with higher rates in the southern region. Consumption was higher in extreme age groups and winter season, with peaks in flu syndromes.
Background In Italy both the consumption of antibiotics and the prevalence of bacterial resistance are higher than in other European countries. In 2017, the first National Action Plan on Antimicrobial Resistance (PNCAR) was adopted in Italy. In response to the PNCAR two national reports on antibiotic use in the human setting have been published. This article's aim is to describe the pattern of antibiotic consumption in the community setting in Italy from 2013 to 2018. Methods To analyse the consumption for reimbursed antibiotics dispensed by community pharmacies different data sources were used. Consumption was measured in terms of defined daily dose (DDD), prescriptions or prevalence of use. Results In 2018, the consumption of antibiotics in Italy amounted to 16.1 DDD per 1000 inhabitants per day. The rates of consumption by geographical area were: 12.7 DDD in the north, 16.9 in the centre and 20.4 in the south. The use was greater in the extreme age groups than in the population aged from 20 to 64 years. The consumption was higher in winter season, with high peaks in the incidence of flu syndromes. In the paediatric population, a utilization rate of 1010 prescriptions per 1000 children, with a prevalence of use of 40.8%, was found. Conclusion The study provides useful information on the geographical variability of antibiotic use in Italy to guide decision makers in the introduction of tailored interventions, as suggested by PNCAR, aimed at promoting a more rational use of antibiotics for humans and reducing antimicrobial resistance.
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