Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 183, Issue 1, Pages 227-237Publisher
SPRINGER
DOI: 10.1007/s10549-020-05726-y
Keywords
Alpelisib; BYL719; Rash; PI3K; PIK3CA; Adverse event
Categories
Funding
- NIH/NCI Cancer Center Support Grant [P30 CA008748]
- Medical Scientist Training Program grant from the NIH [T32GM007739]
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Purpose Rash develops in approximately 50% of patients receiving alpelisib for breast cancer, often requiring dose modifications. Here, we describe the clinicopathologic, laboratory, and management characteristics of alpelisib-related dermatologic adverse events (dAEs). Methods A single center-retrospective analysis was conducted. Data were abstracted from electronic medical records. Results A total of 102 patients (mean age 56 years, range 27-83) receiving alpelisib most frequently in combination with endocrine therapy (79, 77.5%) were included. We identified 41 (40.2%) patients with all-grade rash distributed primarily along the trunk (78%) and extremities (70%) that developed approximately within two weeks of treatment initiation (mean 12.8 +/- 1.5 days) and lasted one-week (mean duration 7.1 +/- 0.8 days). Of 29 patients with documented morphology of alpelisib-related dAEs, 26 (89.7%) had maculopapular rash. Histology showed perivascular and interface lymphocytic dermatitis. All-grade rash correlated with an increase in serum eosinophils from 2.7 to 4.4%,p < 0.05, and prophylaxis with non-sedating antihistamines (n = 43) was correlated with a reduction of grade 1/2 rash (OR 0.39,p = 0.09). Sixteen (84.2%) of 19 patients with grade 3 dAEs resulted in interruption of alpelisib, which were managed with antihistamines, topical and systemic corticosteroids. We did not observe rash recurrence in 12 (75%) patients who were re-challenged. Conclusions A maculopapular rash associated with increased blood eosinophils occurs frequently with alpelisib. While grade 3 rash leads to alpelisib therapy interruption, dermatologic improvement is evident with systemic corticosteroids; and most patients can continue oncologic treatment at a maintained or reduced dose upon re-challenge with alpelisib.
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