Journal
BLOOD
Volume 136, Issue 4, Pages 429-440Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.2019000953
Keywords
-
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP17H06537]
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Ichiro Kanehara Foundation
- SENSHIN Medical Research Foundation
- Japanese Society of Hematology research grant
- Friends of Leukemia Research Fund
- National Institutes of Health National Institute of Allergy and Infectious Diseases [K23 AI123595-04]
- Rogel Cancer Center Scholarship
Ask authors/readers for more resources
Acute graft-versus-host disease (GVHD) is 1 of the major life-threating complications after allogeneic cell trans-plantation. Although steroids remain first-line treatment, roughly one-half of patients will develop steroid-refractory GVHD (SR-GVHD), which portends an extremely poor prognosis. Many agents that have shown encouraging re-sponse rates in early phase 1/2 trials for prevention and treatment have been unsuccessful in demonstrating a sur-vival advantage when applied in the setting of SR-GVHD. The discovery of novel treatments has been further com-plicated by the absence of clinically informative animal models that address what may reflect a distinct patho-physiology. Nonetheless, the combined knowledge of established bone marrow transplantation models and re-cent human trials in SR-GVHD patients are beginning to illuminate novel mechanisms for inhibiting T-cell signaling and promoting tissue tolerance that provide an increased understanding of the underlying biology of SR-GVHD. Here, we discuss recent findings of newly appreciated cellular and molecular mechanisms and provide novel translational op-portunities for advancing the effectiveness of treatment in SR-GVHD. (Blood. 2020;136(4):429-440)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available