Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 117, Issue 9, Pages 2658-2667Publisher
WILEY
DOI: 10.1002/bit.27447
Keywords
antioxidant activity; cell survival; exosome therapy; human hepatic progenitor cells-derived exosome (EXOhCdHs); liver disease
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Funding
- National Research Foundation of Korea [2017R1A5A2015395, 2018M3A9H1023323, 2018M3A9H1023910, 2018R1A2B6005354]
- National Research Foundation of Korea [4220200313796] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The emerging field of regenerative medicine has revealed that the exosome contributes to many aspects of development and disease through intercellular communication between donor and recipient cells. However, the biological functions of exosomes secreted from cells have remained largely unexplored. Here, we report that the human hepatic progenitor cells (CdHs)-derived exosome (EXOhCdHs) plays a crucial role in maintaining cell viability. The inhibition of exosome secretion treatment with GW4869 results in the acceleration of reactive oxygen species (ROS) production, thereby causing a decrease of cell viability. This event provokes inhibition of caspase dependent cell death signaling, leading to a ROS-dependent cell damage response and thus induces promotion of antioxidant gene expression or repair of cell death of hypoxia-exposed cells. Together, these findings show the effect of exosomes in regeneration of liver cells, and offer valuable new insights into liver regeneration.
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