Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 127, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2020.110108
Keywords
Ferroptosis; Inflammation; Anti-inflammatory
Funding
- National Natural Science Foundation of China [81874380, 81672932, 81730108, 81973635]
- Zhejiang Provincial Natural Science Foundation of China for Distinguished Young Scholars [LR18H160001]
- Zhejiang province science and technology project of TCM [2019ZZ016]
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Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.
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