4.3 Article

Plasma albumin levels predict risk for nonsurvivors in critically ill patients with COVID-19

Journal

BIOMARKERS IN MEDICINE
Volume 14, Issue 10, Pages 827-837

Publisher

FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2020-0254

Keywords

albumin; biomarkers; COVID-19; critically ill patients; infection; pneumonia

Funding

  1. Health and Family Planning Commission of Wuhan City [WX18M02, WX18C25]

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We aimed to explore the biomarkers for disease progression or the risk of nonsurvivors. Materials & methods: This study included 134 hospitalized patients with confirmed COVID-19 infection. The outcome of moderate versus severe versus critically ill patients and survivors versus nonsurvivors were compared. Results: An increase in the severity of COVID-19 pneumonia was positively associated with lower levels of platelets and albumin (all p < 0.05). In the critical group, the plasma levels of albumin continued to have a significant association for the risk of nonsurvivors (p < 0.05), even after adjusting for confounding factors. Conclusion: Albumin levels could be used as an independent predictor of the risk of nonsurvivors in critically ill patients with COVID-19.

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